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Selected Publications

  1. Chakraborty, U., Shen, Z.J., and Tyler, J. Chaperoning histones at the DNA repair dance (2021) DNA Repair 108:103240

  2. Mohan, C., Das, C., and Tyler, J. Histone and chromatin dynamics facilitating DNA repair (2021) DNA Repair 107:103183

  3. Chen, B.R., Wang, Y., Tubbs, A., Zong, D., Fowler, F.C., Zolnerowich, N., Wu, W., Bennett, A., Chen, C.C., Feng, W., Nussenzweig, A., Tyler, J.K., Sleckman, B.P. LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells (2021) ELife 10:e68466

  4. Chen, C.C., Chen, B.R., Wang, Y., Curman, P., Beilinson, H.A., Brecht, R.M., Liu, C.C., Farrell, R.J., de Juan-Sanz, J., Charbonnier, L.M., Kajimura, S., Ryan, T.A., Schatz, D.G., Chatila, T.A., Wikstrom, J.D., Tyler, J.K., Sleckman, B.P., Sarco/endoplasmic reticulum Ca2+/-ATPase (SERCA) activity is required for V(D)J recombination (2021) J. Exp. Med 218(8):e20201708

  5. Plummer, J.D., Postnikoff, S.D., Tyler, J.K., and Johnson, J.E. Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice. (2021) ELife 10:e62483

  6. Kaeberlein, M. and Tyler, J.K. A new era for research in aging (2021) ELife 10:e65286

  7. Shen, Z.J., Postnikoff, S., and Tyler, J.K. Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan? (2019) Current Genetics 65(3):717-720 7

  8. Gomes, A.P., Ilter, D., Low, V., Rosenaweig, A., Shen, Z.J., Schild, T., Rivas, M.A., Er, E.E., McNally., D.R., Mutvei, A.P., Han, J., Ou, Y., Cavaliere, P., Mullarky, E., Nagiec, M., Shin, S., Yoon, S.O., Dephoure, N., Massague, J., Melnick, A.M., Cantley, L.C., Tyler, J.K. and Blenis, J. Dynamic incorporation of histone H3 variants into chromatin is essential for acquisition of aggressive traits and metastatic colonization. (2019) Cancer Cell 25(4):402-417 7

  9. Hu, Z., Xia, B., Postnikoff, S., Shen, Z-J, Harkness, T.A., Seol, J-H, Tomoiaga, A.S , Li, W., Chen, K and Tyler, J.K Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan. (2018) eLife August 17; 7

  10. Huang, T, Fowler, F, Chen, C-C, Shen, Z-J, Sleckman, B and Tyler, J.K. Replication-dependent chromatin assembly plays an active role in DNA double-strand break repair by promoting Rad51 nucleofilament formation (2018) Molecular Cell Jul 25:1-12

  11. Hung PJ, Johnson B, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chadhuri J, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP. MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining (2018) Molecular Cell 71(2) 332-342

  12. Huang, T-H, Shen, Z-J, Sleckman, BP, Tyler, JK. The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks (2018) Cell Cycle 69(5) 879-892

  13. Pal, S, Postnikoff, S, Chavez, M and Tyler, J.K. Impaired cohesion and homologous recombination during replicative aging in budding yeast (2018) Science Advances 4(2)

  14. Tyler, J.K. and Johnson, J. The Role of Autophagy in the Regulation of Yeast Lifespan (2017) Annals of the New York Academy of Science Jan 24

  15. Postnikoff, S., Johnson, J. and Tyler, J.K. The integrated stress response in budding yeast lifespan extension (2017) Microbial Cell 4(11):368-375

  16. Fowler, F., and Tyler, J.K. Anchoring chromatin loops to cancer (2017) Developmental Cell. 43(3)2009-2011

  17. Wang, P., Byrum, S., Fowler, FC., Pal, S., Tackett, AJ. and Tyler, JK. Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break (2017) Nucleic Acids Research. 45(19): 10923-10940.

  18. Diao, L, Chen, C-C, Dennehey, B, Pal, S., Deem, A and Tyler, JK. The role of chromatin assembly and the Rtt101/Mms1/Mms22 E3 ubiquitin ligase complex in checkpoint recovery after DNA double-strand break repair (2017) PlOS One. 12(7): e0180556.

  19. Aguilar, R. and Tyler, J.K. Thinking outside the cell: Replicating replication in vitro (2017) Molecular Cell. 65(1):5-7.

  20. Tyler, J.K. Nucleosomes find their place (2016) Trends in Genetics. 32(11):689-690.

  21. Lee, SS and Tyler, JK. Stressed-out chromatin promotes longevity. (2016) Nature. 534: 625-6.

  22. Pal, S and Tyler, JK. Epigenetics and Aging. (2016) Science Advances. 2(7).

  23. Hung PJ, Chen BR, George R, Liberman C, Morales AJ, Colon-Ortiz P, Tyler JK, Sleckman BP, Bredemeyer AL. Deficiency of XLF and PAXX Prevents DNA Double-Strand Break Repair by Non-homologous End Joining in Lymphocytes. (2016) Cell Cycle. Nov 10:0.

  24. Liu, WH, Roemer, SC, Zhou, Y, Shen, ZJ, Dennehey, BK, Balsbaugh, JL, Liddle, JC, Nemkov, T, Ahn, NG, Hansen KC, Tyler, JK, Churchill, MEA. The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes Histones (2016) Elife. Sep 30;5.

  25. Hossain, MB, Fueyo-Margareto, J, Shifat, R, Sulman, EP, Johnston, D, Hung, MC, Bedford, M, Lu, X., Tyler, J.K., Lang, FF, Jiang, H, Gomez-Manzano. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. (2016) Science Advances. Apr 1;2(4).

  26. Li, X., and Tyler, J.K. Nucleosome disassembly during non-homologous end joining in human cells, followed by concerted HIRA- and CAF-1-dependent chromatin reassembly. (2016) Elife. Jun 8:5.

  27. Wike, CL, Graves, HK, Wason, A., Byrum, S, Hawkins, R, Tackett, AJ, Gopalakrishnan, J., Schumacher, J and Tyler, J. Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans. (2016) Cell Cycle. June 1:0.

  28. Pal, S, Graves, HK, Ohsawa, R, Huang, T-h, Wang, P., Harmacek, L., Tyler, JK. The commercial antibodies widely used to measure H3 K56 acetylation are non-specific in human and Drosophila cells. (2016) PLoS One. May 17:11.

  29. Graves, H., Wang, P-P., Lagarde, M., Chen, Z., Tyler, J.K. Mutations that prevent or mimic persistent post-translational modification of the histone H3 globular domain cause lethality and growth defects in Drosophila. (2016) Epigenetics Chromatin. Feb 29; 9:9.

  30. Wike CL, Graves HK, Hawkins R, Gibson MD, Ferdinand MB, Zhang T, Chen Z, Hudson DF, Ottesen JJ, Poirier MG, Schumacher J, Tyler JK. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. (2016) Elife Feb 16;5.

  31. Chen K, Hu Z, Xia Z, Zhao D, Li W, Tyler JK. The overlooked fact: fundamental need of spike-in controls for virtually all genome-wide analyses. (2015) Molecular and Cellular Biology 36(5):662-7.

  32. Gupta A, Hunt, CR, Hegdec ML, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK. MOF Phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice (2014) Cell Reports. 8(3), 177-89.

  33. Castillo A, Paul A, Sun B, Huang T-H, Wang Y, Yazinski SA, Tyler JK, Li K, You MJ, Zou L, Yao J and Wang B. The BRCA1-interacting protein, Abraxas, is required for genomic stability and tumor suppression (2014) Cell Reports. 8(3) 807-17.

  34. Das, C., Roy, S., Namjoshi, S., Malarkey, C.S., Jones, D.N.M, Kutateladze, T.G., Churchill, M.E.A., and Tyler, J.K. Recognition of acetylated histone H3 lysine 56 and the histone chaperone ASF1 by the CBP bromodomain promotes acetylation of non-chromatin bound histones. (2014) PNAS111(12), E1072-81.

  35. Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol J-H, Chen C-C, Li W, Tyler JK (2014) Nucleosome loss leads to global transcriptional upregulation and genomic instability during yeast aging. Genes and Development 15;28(4):396-408. PMID: 24532716

  36. Hammond SL, Byrum SD, Namjoshi S, Graves HK, Dennehey BK, Tackett AJ, Tyler JK (2014) Mitotic phosphorylation of histone H3 threonine 80. Cell Cycle 13(3). PMID: 24275038

  37. Dennehey BK, Noone S, Liu WH, Smith L, Churchill MEA, Tyler JK (2013) The C-terminus of the histone chaperone Asf1 crosslinks to histone H3 in yeast and promotes the interaction with histones H3 and H4. Molecular and Cellular Biology 33(3), 605-21. PMID: 23184661

  38. Chen K, Xi Y, Pan X, Li Z, Kaestner K, Tyler JK, Dent S, He X, Li W (2013) DANPOS: Dynamic Analysis of Nucleosome Position and Occupancy by Sequencing. Genome Research 23(2)341-51. PMID: 23193179

  39. Ohsawa R, Seol J-H, Tyler JK (2013) At the intersection of non coding RNAs, DNA repair, chromatin structure and cellular senescence. Frontiers in Genetics 4:136. PMID: 23967007

  40. ennehey B, Tyler JK (2013) Chromatin assembly and disassembly during DNA repair and DNA replication. Chapter 2, Fundamentals of Chromatin. Edited by J. Workman.

    Budhavarapu V, Chavez M, Tyler JK (2013) How is epigenetic information maintained through DNA replication? Epigenetics and Chromatin 6(1):32. PMID: 24225278

  41. Deem A, Li X, Tyler, JK (2012) Epigenetic Regulation of Genomic Integrity. Chromosoma 121:131-51. PMID: 22249206

  42. Chavez M, Scorgie J, Dennehey B, Noone S, Tyler JK, Churchill M (2012) The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability. Epigenetics and Chromatin 5(1):5. PMID: 22541333

  43. Feser J, Tyler JK (2011) Invited Review, Chromatin structure as a mediator of aging. FEBS letters, published online. PMID: 21081125

  44. Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T, Tyler J (2010) Elevated histone expression promotes life span extension. Molecular Cell 39:724-35. PMID: 20832724

  45. Das C, Tyler JK, Churchill MEA (2010) Invited Review, The histone shuffle: histone chaperones in an energetic dance. Trends in Biological Sciences 35:476-89. PMID: 20444609

  46. Ransom M, Dennehey B, Tyler JK (2010) Chaperoning histones during DNA repair and replication. Cell 140:183-95. PMID: 20141833

  47. Chen C-C, Tyler JK (2009) Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. Cell Cycle 8(18). PMID: 19736512

  48. Ransom M, Williams SK, Dechassa ML, Das C, Linger J, Adkins M, Liu C, Bartholomew B, Tyler JK (2009) FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation. Journal of Biological Chemistry 284(35): 23461-71. PMID: 19574230

  49. Ohsawa R, Adkins M, Tyler, JK (2009) Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators. Epigenetics and Chromatin 2:11. PMID: 19747370

  50. Das C, Lucia S, Hansen K., Tyler JK (2009) CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459, 113-17. PMID: 19270680

  51. Chen C-C, Tyler JK (2008) Chromatin reassembly signals the end of DNA repair. Cell Cycle 7:3792-97. PMID: 19066448

  52. Chen C-C, Carson J, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK (2008) Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134:231-43. PMID: 18662539

  53. Williams S, Truong D, Tyler JK (2008) Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation. Proceedings of the National Academy of Science 105:9000-05. PMID: 18577595

  54. Adkins MW, Williams SK, Linger J, Tyler JK (2007) Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators. Mol Cell Biol 18:6372-82. PMID: 7620413

  55. Linger J, Tyler JK (2007) Chromatin disassembly and assembly during DNA repair. Mutation Research 618:52-64. PMID: 17303193

  56. Williams S, Tyler JK (2007) Transcriptional regulation by chromatin disassembly and reassembly. Current Opinions in Genetics and Development 17:88-93. PMID: 17307351

  57. Adkins MW, Carson JJ, English CM, Ramey JC, Tyler JK (2007) The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase. Journal of Biological Chemistry 12:1334-40. PMID: 17107956

  58. English CM, Adkins MW, Carson JJ, Churchill MEA, Tyler JK (2006) Structural basis for the histone chaperone activity of Asf1. Cell 127:495-508. PMID: 17081973 PMCID: PMC2981792

  59. Linger J, Tyler JK (2006) Global replication-independent histone H4 exchange in budding yeast. Eukaryotic Cell 5:1780-87. PMID: 16936140 PMCID: PMC1595336

  60. Tamburini B, Carson J, Linger JG, Tyler JK (2006) Dominant mutants of the Saccharomyces cerevisiae ASF1 histone chaperone bypass the need for CAF-1 in transcriptional silencing by altering histone and Sir protein recruitment. Genetics 173:599-610. PMID: 16582440

  61. Adkins MW, Tyler JK (2006) Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions. Molecular Cell 3:405-16. PMID: 16455495

  62. Schulz LL, Tyler JK (2006) The histone chaperone ASF1 localizes to active DNA replication forks to mediate efficient DNA replication. FASEB J 20(3):488-90. PMID: 16396992

  63. Tyler JK (2006) Chromatin Assembly Methods. Chapter 38, Cell Biology: a Laboratory Handbook. Edited by Julio E. Celis.

  64. English CM, Maluf NK, Tripet B, Churchill MEA, Tyler JK (2005) ASF1 binds to a heterodimer of histones H3 and H4: a two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA. Biochemistry 44:13673-82. PMID: 16229457

  65. Tamburini B, Carson J, Adkins M, Tyler JK (2005) Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones. Eukaryotic Cell 4:1583-90. PMID: 16151251

  66. Linger J, Tyler JK (2005) The yeast histone chaperone chromatin assembly factor 1 protects against double-strand DNA-damaging agents. Genetics 171:1513-22. PMID: 16143623

  67. Tamburini B, Tyler JK (2005) Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Molecular and Cellular Biology 25:4903-13. PMID: 15923609

  68. Schulz L, Tyler JK (2005) Heterochromatin focuses on senescence. Molecular Cell 17:168-70. PMID: 15664186

  69. Zabaronick S, Tyler JK (2005) The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase. Molecular and Cellular Biology 25:652-60. PMID: 15632066

  70. Adkins MW, Tyler JK (2004) The histone chaperone Asf1p mediates global chromatin disassembly in vivo. Journal of Biological Chemistry 279:52069-74. PMID: 15452122

  71. Ramey CJ, Howar S, Adkins M, Linger J, Spicer J, Tyler JK (2004) Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1. Molecular and Cellular Biology 24:10313-27. PMID: 15542840

  72. Adkins M, Howar S, Tyler JK (2004) Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes. Molecular Cell 14:657-66. PMID: 15175160

  73. Tyler JK (2002) Chromatin assembly: cooperation between histone chaperones and ATP-dependent nucleosome remodeling activities. European Journal of Biochemistry 269:2268-74. PMID: 11985607

  74. Tyler JK*, Collins KA, Prasad-Sinha J, Amiott E, Bulger M, Harte PJ, Kobayashi R, Kadonaga JT (2001) Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Molecular and Cellular Biology 21:6574-84. *Corresponding author. PMID: 11533245

  75. Tyler, JK, Adams CR, Chen S-R, Kobayashi R, Kamakaka RT, Kadonaga JT (1999) The RCAF complex mediates chromatin assembly during DNA replication and repair. Nature 402:555-60. PMID: 10591219

  76. Tyler, JK, Kadonaga JT (1999) The "dark side" of chromatin remodeling: repressive effects on transcription. Cell 99:443-46. PMID: 10589670

  77. Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT (1996) The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Molecular and Cellular Biology 16:6149-59. PMID: 8887645